A.E. Proshchina
Plasticity of the endocrine part of human pancreas
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For a long time it was thought that pancreatic response to increased metabolic demand on insulin secretion is very limited. Currently, there is strong evidence for plasticity of the endocrine part of human pancreas and its adaptation capacity. The aim of this brief review was to discuss the morphogenetic plasticity of the endocrine part of human pancreas in normal physiological conditions (prenatal and postnatal development) and in conditions of impaired carbohydrate metabolism with special reference to the data obtained over the last decade in the laboratory of nervous system development of the Institute of Human morphology.
Key words: plasticity, pancreatic endocrine cells, islets of Langerhans, neuro-insular complexes, diabetes mellitus